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反义缺氧诱导因子抑制胶质瘤的实验研究 被引量：2

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摘要 研究表明许多人类肿瘤内都有显著的缺氧区域。处于缺氧状态的肿瘤细胞仍能不断增殖、浸润，许多基因表达的改变依赖于缺氧诱导因子-1（hypoxia inducible factor，HIF-1）所调节。HIF-1是DNA结合的异质二聚体，由HIF-1α和HIF-1β构成。作者构建了反义HIF-1α（antisense hypoxia inducible factor 1α，aHIF）重组质粒，建立裸鼠C6胶质瘤皮下模型，研究aHIF对胶质瘤血管生成、细胞凋亡和生长的影响作用，并对其作用机理做了初步探讨。
作者 刘猛 吴承远 刘玉光 朱树干 张良文 孙学英
机构地区 山东大学齐鲁医院神经外科 山东大学齐鲁医院普外科
出处 《中华神经外科杂志》 CSCD 北大核心 2006年第9期574-576,共3页 Chinese Journal of Neurosurgery
关键词 缺氧诱导因子 抑制胶质瘤 反义 HIF-1Α 实验研 胶质瘤血管生成 多基因表达
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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二级参考文献21

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共引文献6

同被引文献39

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中华神经外科杂志
2006年 第9期

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