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与服用文拉法辛相关的QT间期延长

QT interval prolongation associated with venlafaxine administration
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摘要 A significant number of non-antiarrhythmic drugs including psychotropic agent s have been shown to prolong cardiac repolarization increasing the risk for tors ade de pointes ventricular tachycardia. We briefly describe a 60-year-old woman who admitted to the hospital due to hypertension and mild dyspnea having a prolonged QT interval(QTc: 582 ms). The patient had a known his tory of depression treated with venlafaxine. The QT interval normalised a few da ys after cessation of the antidepressant agent. This is the first report of venl afaxineinduced QT interval prolongation. A significant number of non-antiarrhythmic drugs includ- ing psychotropic agents have been shown to prolong cardiac repolarization increasing the risk for torsade de pointes ventricular tachycardia. We briefly describe a 60-year-old woman who admitted to the hospital due to hypertension and mild dyspnea having a prolonged QT interval(QTc: 582 ms). The patient had a known history of depression treated with venlafaxine. The QT interval normalised a few days after cessation of the antidepressant agent. This is the first report of venlafaxineinduced QT interval prolongation.
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