麻杏石甘提取物对模型大鼠抗哮喘作用机制研究

Study on the Anti-asthma Mechanism of Action of Maxing Shigan Extract on Asthma Model Rats

目的研究麻杏石甘提取物(ME)对哮喘模型大鼠抗哮喘作用的机制。方法复制卵清蛋白致敏哮喘大鼠模型,观察ME对大鼠体重、引喘潜伏期、白细胞计数及分类、血液与肺组织中内皮素-1(ET-1)含量及肺部病理学改变的影响。结果ME对哮喘模型大鼠有增加体重,延长引喘潜伏期,恢复机体的白细胞数目及正常分布,降低血及肺组织中ET-1含量,改善肺部支气管组织病理形态学结构等作用。结论抑制ET-1的释放可能为ME抗哮喘作用机制之一。

OBJECTIVE：To investigate the anti - asthma mechanism of Maxing shigan extract （ME） on the asthma model rats.METHODS： Rats models of asthma were induced with egg albumin, the indexes of weight, cough incubation period, leukocytes＇ count and classification in the blood,ET - 1 content in the blood and the lung tissue,and lung＇s pathological structure of the asthma rats were detected. RESULTS： ME could increase the weight, prolong the cough incubation period, help to normalize the count and distribution of leukocytes, reduce the ET- 1 content in the blood and the lung tissue, and improve the bronchi＇s and the lung＇s pathological structure of the asthma rat .CONCLUSION： It may be one of the anti- asthma mechanisms of ME that it inhibits the release of ET- 1.