复方甘草酸苷预防抗结核药物致肝损伤的疗效观察

Compound Glycyrrhizin in the Prevention of Liver Injury Induced by Antituberculosis Drugs

目的：评估复方甘草酸苷预防抗结核药物致肝损伤的疗效。方法：180例肺结核住院患者随机分为2组，对照组90例服用抗结核药物6个月～8个月，观察组90例在对照组用药基础上同时给予复方甘草酸苷片，观察2组治疗过程中肝损伤发生率等指标结果：2组肝损伤发生率分别为32．2％、8．9％（P〈0．01）。结论：复方甘草酸苷能有效预防抗结核药物所致肝损伤。

OBJECTIVE： To evaluate the efficacy of compound glycyrrhizin in preventing liver injury induced by antituberculosis drugs. METHODS： A total of 180 cases with pulmonary tuberculosis were randomly divided into control group and trial group： 90 cases in the control group were treated with antituberculosis drugs alone for 6-8 months, and another 90 cases in the trial group were treated concomitantly with antituberculosis drugs and compound glycyrrhizin, the incidences of liver injury between 2 groups were monitored. RESULTS： The incidences of liver injury of the control group and the trial group were 32.2% and 8.9%, respectively（P〈0.01）.CONCLUSION： Compound glycyrrhizin is effective in preventing liver injury induced by antituberculosis drugs.