雌、孕激素受体与子宫内膜癌预后

AN EVALUATION OF ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR AND PROGNOSIS OF EN DOMETRIAL CARCINOMA

目的总结子宫内膜癌患者病理分化、临床分期和浸润程度及受体状态与生存率的关系。方法对子宫内膜癌手术患者石蜡标本应用免疫组化LSAB法测定雌激素受体(ER)和孕激素受体(PR)。结果5年生存率随肿瘤分化程度低、肌层浸润深和临床分期晚而下降,ER和PR阳性率也呈下降趋势。受体阳性者5年生存率为86.5%。结论受体阳性可与组织分化、临床分期及肌层浸润一起作为观察预后指标。

Objective To investigate the relationship among endometrial careionma patients pathology differentiation and clinical stage and receptor status and the degree of invasion, and the survival rate. Methods Paraffin - embedded tissue of the patients with endometrial carcinoma surgery detected with immunohistochemical technique LSAB to determine the estrogen receptor（ER） and progesterone receptor（ PR）, and then followed -up. Results The 5 - year survival rate was decreased with a low degree of tumor differentiation,and the clinical advanced stage and deep myometrial invasion. The ER and PR positive rates were declined as well. Patients with receptor positive showed 86. 5% of 5 - year survival. Conclusion Receptor Positive, differentiation, clinical stage and myoinvasion can be considered as a prognostic indicator for endometrial carcinoma.