院内感染不动杆菌药物敏感性检测结果分析

Study on antimicrobial resistance of acinetobacter in nosocomial infection

目的:了解院内感染不动杆菌对常用抗菌药物的耐药状况。方法:收集本院2002年1月～2004年12月住院病人各种感染标本进行不动杆菌的培养鉴定和药敏试验,细菌鉴定用MicroScanWalkAway-40(美国DADE公司)全自动微生物分析仪及配套的NC21板,药敏试验用琼脂纸片(Kirby-bauerMethod)扩散法。结果:通过对108株不动杆菌耐药性分析,结果显示碳青霉类抗生素亚胺培南、美洛培南对不动杆菌的抗菌活性最高,分别为93.5%,95.4%,其次为头孢哌酮/舒巴坦、氨芐西林/舒巴坦,为56.5%和42.6%。结论:不动杆菌呈多重耐药性,应加强耐药监测,合理使用抗生素,控制耐药菌株的流行。

Objective：To evaluate the isolation rate and antimicrobial resistance of acinetobacter in nosocomial infection. Methods： The bacteria were identified by MicroScan WalkAway-40,the antimicrobial susceptibility tests were performed by Kirby-bauer Method based on the National Committee for Clinical laboratory Standard （NCCLS）.Various specimens of infection obtained from January 2002 to December 2004.Results：Among the 108 strains, imipenem and meropenem had the most powerful antibacterial activity,the resistant rate of was 93.5% ,95.4% respectively ,the next was cefoperazone/sulbactam and ampicillin/sulbactam.The resistant rate of was 56.5% and 42.6% respectively.Conclusion：The isolation rate of acinetobacter was rather high in nosocomial infection,the resistant rates of acinetobacter to the antimicrobials were high,so it is very important to select antibiotics according to the results of susceptibility tests so as to decrease events of drug resistance of bacterium and prevent the occurrence of nosomial infection.