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近红外光谱法快速测定复方氯丙那林溴己新胶囊的3种有效成分 被引量:7

Fast analysis of the three effective components in compound clorprenaline bromhexine capsules by near infrared spectroscopy
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摘要 目的:建立复方氯丙那林溴己新胶囊3种有效成分的快速同时测定方法。方法:基于近红外漫反射光谱,利用偏最小二乘法分别建立3种有效成分的多元校正模型。结果:3种有效成分盐酸氯丙那林、盐酸溴己新和盐酸去氯羟嗪的校正模型的相关系数分别为0.9986,0.9986,0.9986;回收率分别为97.80%~100.78%.98.65%~103.96%,98.12%~100.34%。结论:方法准确可靠,可用于该制剂的快速同时测定。 OBJECTIVE To establish an analytical method for the fast and simultaneous determinations of the three effective components contained in the compound clorprenaline bromhexine capsules. METHODS Based on the near infrared diffuse reflectance spectra, the multivariate calibration models of the three effective components were established using the partial least squares method. RESULTS For the calibration models of the three effective components clorprenaline hydrochloride, bromhexine hydrochloride and decloxizine hydrochloride, the correlation coefficients were 0. 998 6, 0. 998 6 and 0. 998 6, respectively; the recovery ratios were 97. 80% - 100. 78%, 98.65% - 103.96% and 98. 12% - 100. 34%, respectively. CONCLUSION The method is accurate and reliable, and it can be applied to the fast and simultaneous determinations for the capsules.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2006年第10期1194-1196,共3页 Chinese Journal of Hospital Pharmacy
基金 化学生物传感与计量学国家重点实验室开放基金(编号:2003-16) 苏州大学优秀中青年学术带头人基金(编号:R2317043)
关键词 近红外光谱 偏最小二乘法 盐酸氯丙那林 盐酸溴己新 盐酸去氯羟嗪 near infrared spectroscopy partial least squares method, clorprenaline hydmchloride bromhexine hydrochloride decloxizine hydrochloride
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