动态血压监测厄贝沙坦治疗高血压的临床疗效

The clinical effect of irbesartan on hypertension assessed by ambulatory blood pressure monitoring

目的:研究厄贝沙坦治疗原发性轻、中度高血压的临床疗效及安全性。方法:入选40例原发性轻、中度高血压患者,随机分为两组,分别给予厄贝沙坦或贝那普利治疗4周,每两周随访一次,并于服药前后进行24h动态血压监测(ABPM)。结果:厄贝沙坦降压总有效率达85.0%,ABPM结果提示其对夜间收缩压和舒张压均有显著性降低(P<0.01)且优于贝那普利(P<0.05),同时不影响血压昼夜节律及心率,无明显不良反应发生。结论:厄贝沙坦降压疗效显著且平稳,安全性好。

OBJECtIVE To investigate the clinical effect and safety of irbesartan on essential mild to moderate hypertension. METHODS Forty patients with essential mild to moderate hypertension were enrolled and arranged randomly to two groups. They were treated with irbesartan or benazepril respectively for 4 weeks and visited every two weeks. 24-hour ambulatory blood pressure monitoring （ABPM） was performed before and after drug administration. RESULTS The total efficacy rate of irbesartan was 85.0%. The night systolic and diastolic blood pressure were reduced significantly observed in ABPM （P〈0. 01 ）, which were better than benazepril （P〈0. 05）. Blood pressure rhythm and heart rate were uninfluenced. No obvious adverse reaction occurred. CONCLUSION the antihypertensive effect of irbesartan is remarkable and steady. The safety is also good.