88例软组织肿瘤临床病理及免疫组化检测

Clinicopathology and immunohistochemistry of 88 patients with soft tissue tumor

目的:探讨软组织肿瘤的病理组织学和免疫组化特点。方法:分析88例软组织肿瘤的临床病理特征及免疫组化特点。结果:88例软组织肿瘤中,男性36例,女性52例。肿瘤的发病平均年龄为44岁;良性病变42例,恶性病变46例。主要包括九大类30种不同的软组织肿瘤,肿瘤的细胞形态可呈梭形、圆形或卵圆形、多形性等。共应用31种不同的抗体行免疫组化检查,主要包括间叶组织标记物波形蛋白(Vimtin),其使用率为93%(82/88);肌性标记物结蛋白(desmin),其使用率为81%(71/88);外周神经标记物S-100蛋白(S-100),其使用率为73%(64/88)。88例软组织肿瘤的诊断率为100%(88/88)。结论:在病理组织学基础上适当的应用免疫组化检查,可以有效地解决软组织肿瘤起源和分类判定中遇到的问题。

Objective：To study the clinicopathology and immunohistochemistry features of Soft tissue tumors.Methods：To analyze the clinicopathology and immunohistochemistry features of 88 patients with soft tissue tumors.Results：Of the 88 patients,36 cases are males and 52 cases are females.The average age of the soft tissuetTumors is 44 years.42 cases are benign pathological changes and 46 cases are malignant pathological changes.These 88 cases can be classified to 9 different kinds or 30 diffirent types.The cells of tumor are representing the different characteristics,such as spindle cells,small-round cells,polymorphic cell and so on.We used 31 different types of antibodys,mostly including vimtin, desmin,S- 100.The use rates of them are 93% （82/88） ,81% （ 71/88 ）,73% （64/88）,respectively.The rate of diagnosis is 100%（88/88）.Conclusion：Base on the histopathology to use the immunohistochemistry examinations properly,we can effectively resolve the problems of genesis and determinant classes for soft tissue tumors.