超声检查在女孩性早熟诊断及治疗中的价值

Ultrasonography in Diagnosis and Treatment of Girls with Precocious Puberty

目的探讨超声检查在女孩性早熟诊断及治疗中的价值。方法应用超声监测52例女孩性早熟患儿的子宫卵巢形态学变化，并对其中24例真性性早熟患儿治疗前后子宫卵巢形态学变化进行对比。结果三类性早熟患儿子宫容积明显增大，真性性早熟及单纯性乳房发育患儿卵巢容积明显增大，真性及假性性早熟患儿宫颈体比增大，内膜增厚，卵巢内可见直径〉4mm卵泡5～9枚；24例真性性早熟患儿经GnRH—A治疗后，子宫卵巢容积，内膜厚度，卵泡直径比治疗前有明显缩小。结论超声检查子宫卵巢形态学变化能间接反映下丘脑-垂体-性腺轴功能状态，评价临床疗效。

Objective To investigate the value of ultrasonography in the diagnosis and treatment of girls with precocious puberty. Methods In 52 girls with precocious puberty, the uterine and ovarian morphologic changes were monitored with ultrasound, and in 24 cases, the morphologic changes before and after treatment were compared. Results Three kinds of precocious puberty revealed increased uterine volume significantly. In girls with true precocious puberty and partial precocious puberty, the ovarian volume was increased significantly. In girls with true and pseudo precocious puberty, uterine cervix/uterine body and endometrial thickness were increased and in one or two sides of the ovary, 5-9 follicles had the diameter 〉4 mm. In 24 girls with true precocious puberty with GnRH-A treatment, the uterine and ovarian volumes and endometrial thickness, the size and the number of follicles were reduced significantly after treatment. Conclusions The uterine and ovarian morphologic changes on ultrasonography can reflect the gonadal axis function indirectly, and evaluate the clinical effects.