中国南方地区鼻咽癌家族史危险因素的Meta分析

Meta-analysis of family history of risk factors associated with nasopharyngeal carcinoma in the southern China

目的 综合评价鼻咽癌家族史在中国南方地区鼻咽癌发病中的作用。方法 应用Meta分析对国内9篇鼻咽癌家族史危险因素的病例对照研究文献进行定量综合分析。结果 家族史危险因素单因素合并OR值为5．05，95％ CI为3．49～7．32；多因素合并OR值为7．20，95％ CI为4．52～11．46。结论 遗传是中国南方地区人群鼻咽癌的重要危险因素，加权计算合并家族史OR值可以综合评价遗传因素的作用。

Objective To evaluate the risk factors of family history of nasopharyngeal carcinoma in south of China. Methods The results of 9 studies on the family history in risk factors of nasopharyngeal carcinoma were analysed by Meta-analysis. Results The univariate and multivariate pooled OR value （95 % CI ） of NPC family history were 5.05 （3.49,7, 32）, 7.20 （4.52,11.46） respectively. Conclusions Heredity was the important risk factor of nasopharyngeal carcinoma, Calculating the weighing mean of pooled OR values of family history could comprehensively appraise the effect of genetic risk factors in occurrence of the disease.