γ-羟基丁酸对脑出血的保护作用的研究

Study of gamma-hydroxybutyric acid (GHBA) in the treatment of cerebral hemorrhage

目的评价γ-羟基丁酸治疗脑出血的临床疗效及其对脑出血后脑水肿的影响。方法60例脑出血病例随机分为γ-羟基丁酸组及对照组,两组均接受神经内科脑出血常规治疗。γ-羟基丁酸组采用γ-羟基丁酸静脉滴注,每日1次,共2周。应用欧洲卒中评分评价临床神经功能情况,利用CT测卒中灶体积。结果γ-羟基丁酸组临床疗效明显优于对照组,治疗后与对照组相比出血灶周围脑水肿体积明显减小。结论γ-羟基丁酸治疗脑出血有效,而且安全。

Objective To evaluate the efficacy and safety of GHBA for the treatment of cerebral hemorrhage. Methods The patients were divided into two groups at random ： GHBA group , placebo group （ control group）. The two groups all accepted routine treatment. GHBA was infused intravenously to the GHBA group once a day for two weeks. The neurological function was evaluated with European stroke scale （ ESS ）, The volume of the surrounding area of intracerebral, hemorrhage （ ICH ） was measured on CT. Results Compared with control group, the neurological function recovered better at 7day,and the volume of the surrounding area of ICH was smaller. Conclusion GHBA was effective＇and safe in the treatment of cerebral hemorrhage.