鼻咽癌患者MDR-1和GST-л耐药蛋白表达的临床意义

Clinical Significance of Expression of P-gp,GST-Resistant Proteinsin Patients with Nasopharyngeal Carcinoma

目的:探讨鼻咽癌患者多药耐药蛋白表达的临床意义。方法:采用WHO病理分类和福州92’鼻咽癌分期,对T3～4,N2～3和T2N1鼻咽癌患者采用同期化疗,T3～4,N2～3患者放射治疗前采用新辅助化疗。采用免疫组化检测45例鼻咽癌标本MDR-1和GST-!的表达。结果:MDR-1表达与鼻咽癌病理类型有关,GST-!与鼻咽癌病理类型无关,而MDR-1和GST-!表达与临床分期和近期疗效均无关。结论:MDR-1和GST-!耐药蛋白表达与鼻咽癌临床分期和近期疗效无关。

Objective： To explore the clinic significance of Multi-drug resistant protein expression in patients with nasopharyngeal carcinoma. Methods： Positive expression rates of P-gp and GST-π protein were determined in the 45 patients with nasopharyngeal carcinoma using immunohistochemistry stain. At the same time, the clinical stages of Fuzhou 1992 and histological types of WHO staged in NPC were ascertained. Those patients, with T3-4, N2-3 and T2N1 stages, were treated with induced chemotherapy and radiotherapy; with T3-4, N2-3 stages, were treated with neoadjuvant chemotherapy . Induction chemotherapy consisted of one to two cycles of cisplatin and fluorouracil. RT was given to the nasopharynx and neck using megavohage radiation. The response of chemotherapy and radiotherapy in NPC patients was evaluated at six months. Results： The expression rate of P-gp was correlated with pathology types and that of GST-π had nothing to do with the pathology types. However, statistical analysis showed an independence between the P-gp and GST-π proteinic expressions and the clinical stage and short-term therapeutic effect. Conclusion： There was no correlation between the expressions of P- gp and GST-π protein and the clinical stage and short-term therapeutic effect.