介入再通联合丹参注射液灌注术治疗输卵管阻塞性不孕症的研究

Fallopian Tubal Recanalization Combined with Saluia Miltiorrltizebge Injection Infusion for the Treatment of Fallopian Tube Obstruction

目的:评价介入再通联合丹参注射液灌注术治疗输卵管阻塞性不孕症的临床疗效。材料和方法:以广州中医药大学第一附属医院自1997年10月-2004年12月间在妇科求治的873例输卵管阻塞性不孕病人为研究对象,采用输卵管介入再通术(FTR),通过导丝和微导管对1449条阻塞输卵管进行机械再通,并经微导管直接造影和注入多种药物,试验组注入丹参注射液、庆大霉素、α-糜蛋白酶及地塞米松;对照组注入庆大霉素、α-糜蛋白酶及地塞米松,试验组术后采用中医内外治疗,随访12个月,观察输卵管通畅度。结果:术后12个月试验组输卵管通畅率为93.61%,对照组术后12个月输卵管通畅率为60.18%。试验组的输卵管通畅率明显高于对照组,输卵管再度阻塞率、通而不畅率明显低于对照组。结论:介入再通联合丹参注射液灌注术对治疗输卵管阻塞性不孕症具有良好的临床疗效;丹参注射液对感染性炎症及机械性损伤输卵管内皮的作用机理值得进一步探讨。

Objective： To observe the curative effect of fallopian tubal recanalization combined with saluia mihiorrhizebge injection infusion for the treatment of fallopian tube obstrution. Methods： There were 541 cases in treatment group and 332 cases in control group. In the treatment group patients were given salvia miltiorrhiza injection infusion by the ductus to the fallopian tube and Chinese herbal medicine after the intervention. In twelfth month a follow up imaging was performed assessing the patency. Results： The patency rate was 93.92% in treatment group,and 60.18% in control group （ P 〈 0.05 ）. Conclusion ： With interventional recanalization combined with salvia mihiorrhiza injection infusion, good curative effect obtained in treatment of fallopian tube obstrutive infertility.