复发性脑膜瘤的细胞增殖和凋亡

Cell proliferation and apoptosis of recurrent meningiomas

目的探讨细胞增殖和凋亡在预测脑膜瘤复发方面的价值。方法应用免疫组化方法检测60例脑膜瘤的增殖细胞核抗原标记指数(PCNALI),并应用TUNEL技术检测肿瘤细胞的凋亡指数(AI),比较复发组与非复发组PCNALI、AI之间的差异。结果复发组的PCNALI(63.1%±15.3%)、AI(0.25%±0.09%)皆显著高于非复发组的PCNALI(47.7%±22.2%)、AI(0.10%±0.09%)。结论脑膜瘤的细胞增殖和凋亡与术后复发关系密切,通过检测PCNALI和AI有助于判断肿瘤的复发倾向。

Objective To explore the value of cell proliferation and apoptosis detection to predict the recurrence ofmeningiomas. Methods Sixty meningiomas were studied to evaluate the proliferating cell nuclear antigen labeling indices （PCNALI） by immunohistochemistry and apoptosis indices （AI） by TUNEL. PCNALI and AI of recurrent group and nonrecurrent group were analyzed to compare the differences between both groups. Results The PCNALI in recurrent group （63.1%±15.3%） was significantly higher than that in nonrecurrent group （47.7%±22.2%）. The AI in recurrent group （0.25%± 0.09%） was also significantly higher than that in nonrecurrent group （0.10%±0.09%）. Conclusion The cell proliferation and apoptosis of meningiomas have a close relation to the recurrence of meningiomas after operation. The detection of PCNALI and AI contributes to predicting the recurrence tendency of meningiomas.