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FcεRIβ编码区E237G基因多态性与哮喘关系的研究 被引量：3

Study on the E237G polymorphism of the FcepsilonRI beta gene with asthma.
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摘要 目的探讨FcεRIβ编码区E237G基因多态性与哮喘、特应性的相关性及与血清总IgE的关系。方法应用限制性片断多态性———聚合酶链技术(RELP-PCR)检测2004年10月至2005年10月山东潍坊市人民医院收治的60例哮喘患者及50名健康对照人群的E237G基因型,结合皮肤过敏原试验及血清总IgE水平分析。结果(1)哮喘组和对照组相比在E237G位点基因型频率(分别为25·00%和22·00%)及G等位基因频率(分别为13·33%和12·00%)差异无显著性意义(P均>0·05)。(2)具有特应性的哮喘患者和对照组相比在E237G位点的基因型频率(分别为34·40%和22·00%)及G等位基因频率(分别为18·97%和22·00%)差异无显著性意义(P均>0·05)。(3)通过单因素方差分析年龄、性别、E237G基因型对血清总IgE的影响差异无显著性意义(P均>0·05)。结论哮喘、特应性与E237G基因突变可能无相关性;哮喘患者E237G不同基因型对血清总IgE可能无影响。 Objective To investigate the E237G polymorphism of the FcepsilonRI beta gene and to investigate its association with asthma, atopy and total serum IgE levels. Methods We chocked the E237G genotype of the FcepsilonRI beta for 60 asthma patients who treated in Weifang People＇s Hospital from 2004. 10 to 2005. 10 and 50 healthy controls through RELP - PCR, combined with skin prick tests and total serum IgE to analyse. Results （ 1 ） No statistical significance between asthma and controls of genotype frequency （25.00% and 22.00% ） and the G allele gene frequency （13.33% andl2. 00% ） on E237G （P 〉 0. 05）. （2） No statistical significance between total atopic asthma and controls of genotype frequency （18.97% and 22. 00% ） and the G allele gene frequency （34.40% and 22. 00% ） on E237G （ P 〉 0. 05 ）. （3） No statistical significance between different year, sex, genotype of E237G and heighten serum total IgE （P 〉 0. 05 ） through one -way ANOVA. Conclusion Maybe there is no association with E237G gene mutation between asthma and atopy.
作者 刘婷 滕琳 管立学 吴立平 孙开宇
机构地区 潍坊市人民医院呼吸科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2006年第10期1520-1522,共3页 Chinese Journal of Practical Internal Medicine
关键词 哮喘 特应性 E237G Asthma Atopy E237Ggenotype
分类号 R5 [医药卫生—内科学]
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同被引文献41

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中国实用内科杂志
2006年 第10期

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