3Oltersdorf T,Elmorc SW,Shoemaker AR,Armstrong RC,Augeri DJ,Belli BA,Bruncko M,Deckwerth TL,Dinges J,Hajduk PJ,Joseph MK,Kitada S,Korsmeyer S J,Kunzer AR,Letai A,Li C,Mitten M J,Nettesheim DG,Ng S,Nimmer PM,O'Connor JM,Oleksijew A,Petros AM,Reed JC,Shen W,Tahir SK,Thompson CB,Tomaselli K J,Wang B,Wendt MD,Zhang H,Fesik SW,Rosenberg SH.An inhibitor of Bcl-2 family proteins induces regression of solid tumours.Nature,2005,435:677～681.
4Gonzalez-Sancho JM,Aguilera O,Garcia JM,PendasFranco N,Pena C,Cal S,Garcia de Herreros A,Bonilla F,Munoz A.The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.Oncogene,2005,24:1098～1103.
5Batlle E,Bacani J,Begthel H,Jonkheer S,Gregorieff A,van de Born M,Malats N,Sancho E,Boon E,Pawson T,Gallinger S,Pals S,Clevers H.EphB receptor activity suppresses colorectal cancer progression.Nature,2005,435:1126～1130.
6Fearon ER,Vogelstein B.A genetic model for eolorectal tumorigenesis.Cell,1990,61:759～767.
70Rajagopalan H,Jallepalli PV,Rago C,Velculescu VE,Kinzler KW,Vogelstein B,Lengauer C.Inactivation of hCDC4 can cause chromosomal instability.Nature,2004,428:77～81.
8Zhang H,Richards B,Wilson T,Lloyd M,Cranston A,Thorburn A,Fishel R,Meuth M.Apoptosis induced by overexpression of hMSH2 or hMLH1.Cancer Res,1999,59:3021～3027.
9Giaretti W,Venesio T,Prevosto C,Lombardo F,Ceccarelli J,Molinu S,Risio M.Chromosomal instability and APC gene mutations iu human sporadic colorectal adenomas.J Pathol,2004,204:193～199.
10van de Wetering M,Sancho E,Verweij C,de Lau W,Oving I,Hurlstone A,van der Horn K,Batlle E,Coudreuse D,Haramis Al,Tjon-Pon-Fong M,Moerer P,van den Born M,Soete G,Pals S,Eilers M,Medema R,Clevers H.The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.Cell,2002,111:241～250.
