慢性胃炎患者消化不良症状、胃动力功能及有关因素的多中心调研

A multicenter study on dyspepsia symptoms,gastric motor function,and related factors in patients with chronic gastritis

目的调查慢性胃炎患者消化不良症状、胃动力功能,并探讨有关的发病因素。方法对全国25家医院门诊胃镜诊断为慢性胃炎的745例患者进行问卷调查,包括一般资料、消化不良症状,分析胃黏膜糜烂和非糜烂患者的症状、胃对不透X线标志物的排空功能以及有关因素的影响。结果745例慢性胃炎患者中,最常见症状是饱胀感、上腹不适、上腹痛和暖气,分别占73．4%、63．1%、61．3%和52．2%；除上腹痛和暖气外,慢性胃炎有或无黏膜糜烂患者的症状谱相近；除上腹痛外,其余各症状均在餐后更易发生(P＜0．05)。36．4%的慢性胃炎患者胃排空明显减缓,糜烂和非糜烂患者的胃排空明显减慢,分别占39．0%和34．7%。结论糜烂和非糜烂慢性胃炎患者除上腹痛外,两组均表现为消化不良症状,胃动力功能异常是慢性胃炎不可忽视的因素。

Objective To investigate dyspepsia symptoms, gastric motor function and related factors in patients with chronic gastritis. Methods Seven hundreds and forty-five patients with chronic gastritis diagnosed by gastroscopy in 25 medical centers were enrolled, and completed questionnaire including general information and 9 symptoms including epigastric fullness, discomfort, epigastric pain, belching, early satiety, nausea, vomiting, acid regurgitation and heartburn. A detailed information observed via endoscopy, including mucosa lesion with or without erosion, bleeding, bile reflux and their location, was recorded. At least one test was used to detect Helicobacter pylori infection in those patients. Patients received gastric emptying 5 hours after a standard test meal and 20 radio-opaque markers. Results The most common symptoms found in patients with chronic gastritis were epigastric fullness, discomfort, epigastric pain and belching, which were account for 73.4%, 63. 1%, 61.3% and 52.2%, respectively. Dyspepsia symptoms in patients with or without erosion were very similar, exceptions were higher percentage of epigastric pain and lower percentage of belching in those with erosive gastritis. Dyspepsia symptoms significantly increased after meal in both groups with or without erosion except to epigastric pain. Thirty six point four percentage of patients with chronic gastritis showed delayed gastric emptying, no significant difference between patients with or without erosion. Conclusions Dyspepsia symptoms are major manifestation in chronic gastritis patients with or without erosion except epigastric pain. Gastric dysmotility is not a negligible factor.