功能磁共振在大脑皮质发育障碍患者的初步应用研究

A basic study of functional magnetic resonance imaging in patients with disorders of cerebral cortical development

目的:应用功能磁共振(fMRI)探讨6名正常受试者及2例皮质发育障碍(DCDs)患者在进行汉语词汇加工过程中脑激活模式,探讨DCDs患者与正常受试者之间脑激活区域的差异与临床意义。方法:本实验采用听觉刺激,以汉语单词理解为语言作业任务。结果:①正常受试者均出现显著的脑区激活,传统语言脑区Wernicke和Broca区激活在双侧大脑半球基本是对称的。除传统语言脑区激活外,还出现其它脑区激活现象。②两例DCDs患者表现为基本语言功能区的激活,诸如Wernicke区和Broca区激活。但脑激活表现为显著的不对称性,甚至完全偏侧性。结论:fMRI能够对大脑DCDs患者功能重塑皮质进行定位,为DCDs伴难治性癫痫患者手术治疗,避免损伤重要功能区提供了有益的保障。

Objective： To employ functional magnetic resonance imaging （fMRI） to define the cerebrum activation patterns concerned with processing of Chinese language and discuss difference between DCDs patients and healthy people and its clinical significance. Methods：We collected 6 healthy people and 2 male DCDs patients. By means of hearing, those subjects were required to finish semantic judgement tasks of Chinese characters separately.Results：①All healthy subjects demonstrated significant activation of associated cerebral regions. Activated Wemicke and Broca areas were symmetric between both cerebral hemispheres. Except for classical regions involved in language actions, there appeared other activated cerebral regions. ② Two patients with DCDs demonstrated activation of basical cerebral regions such as Wemicke and Broca areas. Activated regions were asymmetric between both cerebral hemispheres. Conclusions： fMRI can map the functional localizations of remolding cortex of DCDs patients. It provides guarantee for patients with DCDs and refractory epilepsy that damaging of crucial functional cortex to avoid from lesions when operation is performed.