摘要
目的探讨p27k ip1、MMP-9和α-Caten in在皮肤鳞状细胞癌(SCC)中的表达水平和意义。方法应用免疫组化SP染色法检测30例皮肤鳞状细胞癌、12例不典型增生(AH)和10例脂溢性角化病(SK)皮损中p27k ip1、MMP-9和α-Caten in蛋白的表达。结果①p27k ip1在皮肤SCC表达的阳性率为30%(9/30),显著低于在脂溢性角化病中的表达(P<0.05))。②MMP-9在皮肤SCC表达的阳性率为77%(23/30),显著高于在脂溢性角化病中的表达(P<0.05)。③α-Caten in在皮肤SCC异常表达率为80%(24/30),明显高于在脂溢性角化病中的异常表达(P<0.05)。④在皮肤SCC中,p27k ip1表达与MMP-9或α-Caten in表达呈负相关(P<0.05);MMP-9和α-Caten in表达呈正相关(P<0.05)。结论p27k ip1、MMP-9和α-Caten in可能与皮肤鳞状细胞癌的发生发展密切相关,可作为判断皮肤鳞状细胞癌生物学行为和预后的重要指标。
Objective To investigate the significance of p27^kip1, MMP - 9 and α- Catenin protenin expression in cutaneous squamous cell carcinomas (SCC). Methods p27^kip1, MMP- 9 and α -Catenin in skin lesions of 30 cases of SCC, 12 cases of AH and 10 cases of SK were detected by using immunohistochemical (S -P) method. Results ①In SCC, the positive rate of p27^kiP1 protein was 30% (9/30). Expression of p27^kiP1 protein was detected in a significantly lower proportion in SCC than that in SK ( P 〈 0.05).②In SCC, the positive rate of MMP -9 protein was 77% (23/30). Expression of MMP -9 protein was detected in a significantly highter proportion in SCC than that in SK ( P 〈 0.05). ③In SCC, the abnormal expression rate of α - Catenin was 80% (24/30). Abnormal expression rate of α - Catenin protein was detected in a significantly highter proportion in SCC than that in SK ( P 〈0.05 ). ④In SCC, p27^kip1 expression was negatively correlated with MMP- 9, as well as α-Catenin( P 〈0.05), but MMP-9 expression was positively associated with α- Catenin. Conclusion p27^kip1 , MMP -9 and α- Catenin may be closely related to the carcinogenesis and progression of cutaneous squamous cell carcinoma, and may be as the indication of biological behavior and prognosis of squamous cell carcinoma.
出处
《中原医刊》
2006年第20期6-8,共3页
Central Plains Medical Journal