脑肿瘤相关影响因素病例对照研究

Case-control study on related infection factors of brain tumor

目的分析食物营养素及相关影响因素与脑肿瘤的关系。方法采用1∶2配比的病例对照研究,调查142例脑肿瘤患者,计算营养素及N-亚硝基化合物的日摄入量,转换为等级资料后,分析其与脑肿瘤的关系及因素间的交互作用。结果单因素分析发现,吸烟与脑肿瘤只在男性中有关联(OR=2.51)。蛋白质、脂肪、碳水化合物、胆固醇、纤维素和胡萝卜素是脑肿瘤的保护因素,但不同摄入量在2种类型的脑瘤中略有差别。N-亚硝基化合物的中及高摄入量与脑胶质瘤有关(OR=3.07,OR=4.08),在脑膜瘤只有高摄入量有关联(OR=3.75)。非条件Logistic分析发现,碳水化合物、胆固醇、吸烟、N-亚硝基化合物及胡萝卜素与N-亚硝基化合物的交互作用项进入了模型。胡萝卜素与N-亚硝基化合物的交互作用差异有统计学意义。结论蛋白质、脂肪、碳水化合物、胆固醇、纤维素和胡萝卜素是脑肿瘤的保护因素,以胆固醇和胡萝卜素最具保护意义。N-亚硝基化合物是脑肿瘤的危险因素,危险随摄入量的增加而增加。

Objective To analyze the relationship between nutrition, related factors and brain tumors. Methods Pared case - control study was used to calculate the consumption of nutrition and N - nitrosamine, and to analyze the risk of factors, multiple factors and interaction. Results In factors analysis, smoking was related to brain tumors in men only （ OR = 2.51, 95 % CI：1. 070-5. 873）. Protein, fat, carbohydrate, cholesterol, fiber and carotene are the protective factors in two kinds of tumor. N - nitrosamine was the risk factor to brain tumor. With increasing levels of consumption of N - nitrosamine, the Odds Ratio increased. For the results of multiple logistic regression, cholesterol, smoke, N - nitrosamine and interaction between carotene and N - nitros,amine were in to models. With carotene - stratified, there was a significant relationship between N - nitrosamine and brain tumors with carotene only at the lowest level of consumption of carotene. Conclusion Protein, fat, earbohydrate, cholesterol, fiber and carotene are the protective factors in two kinds of tumor, but cholesterol and carotene has more protective. N - nitrosamine is a risk factor, the risk increasing with it＇s intake increased. Carotene may be has the function to reduce the risk of N- nitrosamine to brain tumor.