197例HBsAg携带者转归调查

Investigation on transformation of 197 HBsAg carriers

目的了解HBsAg携带者的转归情况。方法对HBsAg携带者进行回顾性问卷调查和血清学检测，了解HBsAg携带者发生阴转及转化为乙型肝炎、肝硬化、肝癌甚至死亡的情况。结果对197名HBsAg携带者进行8年以上的回顾性调查，调查对象平均年龄46．2岁，回顾调查年限8～34年。在此期间2例发生HBsAg阴转；发生乙型肝炎33例、肝硬化9例，肝癌10例；死亡11例，其中9例死于肝癌，2例死于肝硬化；男性发生乙型肝炎、肝硬化和肝癌的男性比例（39／103）远远大于女性（13／94）（X^2=14．61，P〈0．05）。结论HBsAg携带者发生阴转的机率较小，应定期进行体检。

Objective To evaluate the transformation of the hepatitis B virus surface antigen（ HBsAg）earriers. Methods A retrospective questionnaire investigation with serological examine was used in this study to evaluate the transformation of HBsAg carriers. The transformation outcome included the ehronieal Hepatitis B, liver cirrhosis, liver cancer and death. Results 197 Hl3,sAg carriers（mean age of 46.19 ± 9.48 years）were followed up by retrospective study. The follow-up time was over 8 years（from 8 to 34 years）. The cumulative eases of negative Hl3,sAg, ehronieal Hepatitis B, liver cirrhosis and liver cancer were 2, 33, 9 and 10, respectively. The cumulative eases of death were 11, meanwhile 9 died of liver cancer and 2 died of liver cirrhosis. The proportion of ehronieal Hepatitis B, liver eirhosis and liver cancer in the male（39/103）were more than the proportion in the female（19/94） greatly（x^2 = 14.61, P 〈 0.05 ）. Conclusion The probability that the positive Hl3,sAg turned into negative is small. The HBsAg carriers should have body examined frequently.