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环氧化酶-2与前列腺癌研究进展 被引量：1

Cyclooxygenase-2 and prostate cancer
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摘要 环氧化酶-2(COX-2)是花生四烯酸合成前列腺素的限速酶,在人类许多肿瘤中过表达。近年来研究表明,COX-2通过促进肿瘤细胞增殖、抑制肿瘤细胞凋亡、促进肿瘤血管生成以及降低机体免疫力等机制在前列腺癌变过程中发挥着重要作用。现就其研究新进展作一综述。 Cyclooxygenase-2 （COX-2） is the key enzyme regulating the production of prostaglandins. Overexpression of COX-2 is associated with several kinds of tumors. COX-2 plays a important role in prostate carcinogenesis through increasing cell growth and angiogenesis, decreasing apoptosis and immune response. This review will address on the research advancement on the role of COX-2 in prostate cancer.
作者 张月英 张维东
机构地区 山东省医学科学院基础医学研究所实验病理学与生理学研究室
出处 《国际肿瘤学杂志》 CAS 2006年第9期704-706,共3页 Journal of International Oncology
基金 国家自然科学基金资助项目(30371841) 山东省自然科学基金资助项目(Y2003C02)
关键词 前列腺肿瘤 前列腺素内过氧化物合酶 同工酶类 Prostatic neoplasms Prostaglandin-endoperoxide synthase Isoenzymes
分类号 R737.25 [医药卫生—肿瘤]
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参考文献20

  • 1Yoshimura R, Sano H, Masuda C,et al. Expression of cyclooxygenase-2 in prostate carcinoma. Cancer, 2000,89(3 ) :589-596.
  • 2Gupta S, Srivastava M, Ahmad N, et al. Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate,2000,42 ( 1 ) :73-78.
  • 3Sinicrope FA. Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. Mol Carcinog,2006,45 (6) :447-454.
  • 4Liu XH, Kirschenbaum A, Yu K,et al. Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. J Biol Chem,2005,280(5 ) :3817-3823.
  • 5Dannenberg A J, Ahorki NK, Boyle JO, et al. Cyclooxygenase-2 : a pharmacological target for the prevention of cancer. Lancet Oncol, 2001,2(9) :544-551.
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  • 7Roberts RO,Jacobson DJ, Girman CJ, et al. A population-based study of daily nonsteroidal anti-inflammatory drug use and prostate cancer. Mayo Clin Proc ,2002,77(3 ) :219-225.
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  • 9Sabichi AL, Subbarayan V, Llansa N, et al. Peroxisome proliferatoractivated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. Cancer Epidemiol Biomarkers Prey,2004,13 (11 Pt 1 ) :1704-1709.
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同被引文献3

  • 1Wang W, Bergh A, Damber JE. Cyclooxygertase-2 expression correlates with local chronic inflamation and tumor neovascularization in human prostate cancer[ J ]. Clin Cancer Res,2005,11 (9) :3250- 3256.
  • 2Di Lorenzo G,DePlacido S,Autorino R,ct al. Expression of biomarkers modulating prostate cancer progression:implications in the treatment of the disease[ J]. Prostate Cancer Prostatic Dis ,2005,8 (1) : 54-59.
  • 3Panguluri RC ,Long LO ,Chen W ,et al. COX-2 gene promoter haplotypes and prostate cancer risk [ J ]. Carcinogenesis, 2004,25 ( 6 ) : 961-966.

引证文献1

国际肿瘤学杂志
2006年 第9期

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