期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CD4^+CD25^+调节性T细胞与自身免疫性疾病 被引量：2

原文传递
导出
摘要 随着免疫调节功能T细胞亚群的发现，调节性T细胞（regulatory T cell，Treg）的概念被逐渐接受，例如Th3细胞、Tr1细胞等。这些T细胞通过产生具有抑制功能的细胞因子．如白细胞介素（IL）-10和转化生长因子（TGF）-β等发挥作用。而其中CD4^＋CD25^＋细胞具有独特的作用方式和功能特征，由Sakaguchi等于1995年首次报道后即引起广泛关注。目前世界各国的多家实验室致力于CD4^＋CD25^＋细胞的研究工作，并有许多文章和多篇综述发表。
作者 郝慧琴 黄烽
机构地区 解放军总医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 2006年第10期617-620,共4页 Chinese Journal of Rheumatology
基金 国家自然科学基金(30571726)
关键词 CD4^+CD25^+调节性T细胞 自身免疫性疾病 CD25^+细胞 免疫调节功能 转化生长因子 T细胞亚群 Th3细胞 白细胞介素
分类号 R593.2 [医药卫生—内科学]
  • 相关文献

参考文献21

  • 1Sakaguchi S,Wood KJ.Regulatory T cells in transplantation tolerance.Nat Rev Immunol,2003,3:199-210.
  • 2Papiernik M.Natural CD4CD25 regulatory T cells:their role in the control of superantigen responses.Immunol Rev,2001,182:180-189.
  • 3Boden E,Tang Q,Bour-Jordan H,et al.The role of CD28 and CTLA4 in the function and homeostasis of CD4^+CD25^+ regulatory T cells.Novartis Found Dymp,2003,252:55-66.
  • 4Uraushihara K,Kanai T,Ko K,et al.Regulation of murine inflammatory bowel disease by CD25^+ and CD25CD4^+ glucocorticoid induced TNF receptor family related gene regulatory T cells.J Immunol,2003,171:708-716.
  • 5Salomon B,Bluestone JA.Complexities of CD28/B7:CTLA4 costimulatory pathways in autoimmunity and transplantation.Ann Rev Immunol,2001,19:225-252.
  • 6Kingsley CI,Karim M,Bushell AR,et al.CD4^+CD25^+ regulatory T cells prevent graft rejection:CTLA4 and IL-10 dependent immunoregulation of alloresponses.J Immunol,2002,168:1080-1086.
  • 7Cederbom L,Hall H,Ivars F.CD4^+CD25^+ regulatory T cells down regulate costimulatory molecules on antigen presenting cells.Eur J Immunol,2000,30:1538-1543.
  • 8Asseman C,Mauze S,Leach M,et al.An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.J Exp Med,1999,190:995-1004.
  • 9Hori S,Nomura T,Sakaguchi S.Control of regulatory T cells development by the transcription factor Foxp3.Science,2003,299:1057-1061.
  • 10Longhi MS,Ma Y,Bogdanos DP,et al.Impairment of CD4^+CD25^+ regulatory T cells in autoimmune liver disease.J Hepatol,2004,41:31-37

二级参考文献8

  • 1Sakaguchi S, Sakaguchi N, Asano M et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains [J]. J Immunol, 1995; 155:1151-1164.
  • 2Bluestone J A, Abbas A K. Natural versus adaptive regulatory T cells [J]. Nat Rev Immunol,2003;3:253-257.
  • 3Nagler-Anderson C, Bhan A K, Podolsky D K et al. Control freaks: immune regulatory cells [J]. Nat Immunology,2004;5:119-122.
  • 4Wei W Z, Morris G P, Kong Y C. Anti-tumor immunity and autoimmunity: a balancing act of regulatory T cells [J]. Cancer Immunol Immunother,2004;53(2): 73-78.
  • 5Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3 [ J]. Science,2003 ;299:1057-1061.
  • 6Verginis P, Stanford M M, Carayanniotis. Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis [J] .J Immunol,2002; 169:5332-5337.
  • 7Thornton A M, Shevach E M. Suppressor effector function of CD4 + CD25 + immunoregulatory T cells is antigen nonspecific [J]. J Immunol,2000,164:183-190.
  • 8王胜军,许化溪,刘恭植,柳龙图,江淑芳.树突状细胞对小鼠实验性自身免疫性甲状腺炎的作用[J].中国免疫学杂志,1999,15(7):294-295. 被引量：5

共引文献6

同被引文献17

  • 1陈明琪,张林,李虹,蒋中华,庄永华,贾怡,李明远.DT390-IL2重组质粒治疗实验性变态反应性脑脊髓炎的初步研究[J].南京医科大学学报（自然科学版）,2005,25(6):386-388. 被引量：3
  • 2李卫鹏,王福庆.CD4^+CD25^+ Treg的免疫调节作用机制以及临床研究进展[J].现代免疫学,2006,26(2):164-167. 被引量：18
  • 3陈巧英,李大金.CD4^+CD25^+调节性T细胞的生物学特性及功能[J].中国免疫学杂志,2007,23(1):89-92. 被引量：25
  • 4Chen X, Fang L, Song SL, et al. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3^+ regulatory T cells through IL -7 signaling pathway[J]. J Immunol, 2009, 183(10): 6135-6161.
  • 5Tsunoda I, Libbey JE, Kuang LQ, et al. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis [J]. Am J Pathol, 2005, 167(6): 1631-1646.
  • 6Hug A, Korporal M, Schrder I, et al. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis[J]. J Immunol, 2003, 171(1): 432-437.
  • 7Anderson AC, Chandwaskar R, Lee DH, et al. A transgenie model of central nervous system autoimmunity mediated by CD4^+ and CD8^+ T and B cells[J]. J Immunol, 2012, 188(5): 2084-2092.
  • 8Sasaki K, Bean A, Shah S, et al. Relapsing-remitting central nervous system autoimmunity mediated by GFAP- specific CD8 T cells[J]. J Immunol, 2014, 192(7): 3029-3042.
  • 9Germain RN. T-cell Development and the CD4^-CD8 lineage decision[J]. Nat Rev ImmunoL 2002, 2(5): 309-322.
  • 10Yura M, Takahashi I, Serada M, et al. Role of MOG- stimulated Thl type "light up" (GFP+) CD4^+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)[J]. J Immunol, 2001, 17(1): 17-25.

引证文献2

二级引证文献10

中华风湿病学杂志
2006年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部