组织工程与细胞生物力学的进展

Progress of tissue engineering and cell biomechanics

组织工程是由组织学与工程学两门学科组成。它包括组织中的细胞、细胞外基质与工程部分的材料科学及生物力学等跨领域研究。细胞生物力学则包含了单一细胞材料性质的探讨与细胞受力学刺激后,其信息传递、基因与蛋白质表现等改变的一系列研究。组织工程的最终目的是利用工程的方法制造出可取代人体的组织或器官,以解决器官移植中组织或器官取得困难、移植排斥反应仍无法有效避免等难题。因此,若能利用工程的方法制造出可取代人体器官的人造器官,则能为,临床治疗提供极佳的解决方法。本次组织工程与细胞生物力学重点刊共收录了中国大陆7篇(1篇综述)与中国台湾省4篇(1篇综述)相关研究论文,内容涵盖了干细胞的应用、载体的改性、软骨组织工程与细胞受力后的反应,性质从基础到未来可能应用的研究,期望能使读者曼深入了解工程在生物研究与临床应用中的作用与未来的发展,以吸引更多不同领域的研究人员共同加入跨领域的合作工作。

Ahhough composed of two words, tissue and engineering, the term tissue-engineering is an integrated research field which inw）lves living cells, extra-cellular matrix, biomaterial and biomechanics etc. Cell biomechanies includes a series of research on the material properties, signal transduction, gene and protein expression after mechanical stimulation in cells. The ultimate purpose of tissue engineering is to build up tissues or organs in vitro that can replace corresponding human tissues and organs in vivo and work successfully. We hope this technology can help us resolve problems related to organic transplantation, such as rejection and unavailability of human organs in clinic. This special issue featuring tissue-engineering and cell biomeehanies collected six papers from mainlaml China and four papers from Taiwan, which deal with application of stem cells, improvement of scaffolds, tissue-engineered cartilage and response of cells after force stimulation. We hope they can help readers realize the role and application of engineering in biology and clinical research. We also hope investigators in different fields can collaborate with each other.