益气活血中药联合化疗治疗晚期大肠癌的临床研究

Clinical Study on Advanced Colorectal Cancer Treated by Yiqi Huoxue TCM Combined with Chemotherapy

目的观察益气活血中药联合草酸铂+CF+5-FU治疗晚期大肠癌的疗效。方法68例晚期大肠癌患者,分为治疗组(38例,益气活血中药联合化疗)和对照组(30例,单纯化疗),观察两组疗效。结果治疗组和对照组的临床受益率(CR+PR+SD)分别为78.9%、53.3%(P<0.05),1年生存率分别为73.7%、46.7%(P<0.05)。益气活血中药可减低患者的血液高凝状态、提高细胞免疫功能、缓解化疗药物的不良反应、改善患者的生活质量。结论益气活血中药联合草酸铂+CF+5-FU治疗晚期大肠癌有较好的疗效。

Objective To observe the effect of Yiqi Huoxue TCM combined with L-OHP＋CF＋5-FU regimen in treating advanced colorectal cancer patients. Methods 68 advanced colorectal cancer patients were randomly assigned to treatment group （38 patients, treated by Yiqi Huoxue TCM combined with L-OHP＋CF＋5-FU） and control group （30 patients, treated with L-OHP＋CF＋5-FU regimen）. The therapeutic effects of two groups were observed. Result Clinical beneficial rate （CR＋PR＋SD） of treatment group and control group were 78.9% and 53.3% respectively （P〈0.05）, 1-year survival rates were 73.7% and 46.7% （P〈0.05）. Yiqi Huoxue TCM decreased blood hypercoagulability, improved cellular immune function of patients, relieved myelosuppression of chemotherapeutic agents and improved quality of life of patients. Conclusion Yiqi Huoxue TCM combined with L-OHP＋CF＋5-FU Regimen had better effect in treatment of advance colorectal cancer patients.