喉癌中能动性相关蛋白-1的表达与临床病理特征间的关系

Relationship between the level of MRP-1/CD9 and the clinicopathological features of carcinoma of larynx.

目的观察能动性相关蛋白-1(motility-related protein-1,MRP-1/CD9)在喉癌组织中的表达水平及与患者临床病理特征间的关系。方法选取61例喉癌患者手术切除的病理组织标本(喉癌组)、61例癌旁切缘组织标本(对照组,经术后病理证实为非肿瘤组织),其中喉癌组有33例发生颈淋巴结转移。采用免疫组化SP法检测MRP-1／CD9的表达水平,并结合患者的临床病理资料对其结果进行对比分析。结果喉癌组中MRP-1／CD9的表达水平低于切缘对照组(P＜0.05)；喉癌原发灶中MRP-1／CD9表达水平高于颈淋巴结转移灶(P＜0.01)：喉癌伴颈淋巴结转移者MRP-1/CD9的表达水平低于不伴颈淋巴结转移者(P＜0.01),不同临床分期、组织病理分级的患者之间其表达水平差异有显著性。结论MRP-1／CD9的表达在喉癌的发生、发展及转移过程中具有一定作用,可能作为判断喉癌转移潜能和预后的因素之一,为临床了解患者的病情进展提供一定的理论依据。

OBJECTIVE To observe the levels of MRP-1/CD9 expressed in carcinoma of larynx and the relationship between it and their clinicopathological features. METHODS The expressions of MRP-1/CD9 in 61 patients with carcinoma of larynx were detected by immunohistochemistry, there were 33 patients with lymph node metastasis in the neck. Surgical margins （control group） of the carcinoma of larynx were also studied, and the results were compared. RESULTS The expression level of MRP-1/CD9 protein in carcinoma of larynx was lower than that in control group（P〈0.05）; Statistic difference was found between MRP-1/CD9 in primary lesions and metastatic lesions（P〈0.01）;The expression of MRP-1/CD9 was closely correlated with lymph node metastasis（P〈0.01） ; furthermore, the expression was correlated with clinical staging and pathological differentiation （respectively）. CONCLUSION MRP-1/ CD9 may play an important role in development and metastasis of carcinoma of larynx. They may be used as potential marker for metastasis and prognosis in carcinoma of larynx.