摘要
无机砷是一种确认的人类致癌物,但其致癌机制至今仍不很清楚.人类的大多数肿瘤是环境与遗传因素共同作用的结果.砷中毒在不同种属(族)和个体之间存在着明显的差异,除年龄、性别、砷暴露量、营养状况等因素外,近年来研究发现,个体间砷中毒易感性的不同可能与某些基因多态性密切相关,这些基因包括谷胱苷肽-S-转移酶基因、5,10-亚甲基四氢叶酸还原酶基因、着色性干皮病D基因、髓性过氧化物酶基因、过氧化氢酶基因以及p53基因等.只有充分考虑遗传因素的作用,才能深入阐明砷中毒的机制.
Inorganic arsenic is a recognized human carcinogen, but the mechanism of arsenic carcinogenesis is not well understood. There is a variation in acute and chronic toxicity of arsenic among mammalian species and it has also been suggested that there is a marked variation in susceptibility among individuals. In addition to factors such as age, gender, the level of arsenic exposure, nutritional status, recent researched indicated that the variations in susceptibility to arsenic may also be related to genetic polymorphism, such as polymorphism of the genes of GST, MTHFR, XPD, MPO, CAT and p53, etc. Understanding the role of genetic factors is crucial to further clarify the mechanism of arsenic toxicity.
出处
《生态毒理学报》
CAS
CSCD
2006年第3期209-213,共5页
Asian Journal of Ecotoxicology
基金
国家自然科学基金项目(No.30170795)
关键词
砷
基因多态性
易感性
arsenic
genetic polymorphism
susceptibility
