阻塞性睡眠呼吸暂停低通气综合征患者生活质量的相关性研究

Influence of obstructive sleep apnea hypopnea syndrome on the quality of life of the patients

目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopneasyndrome,OSAHS)对患者生活质量的影响。方法对145例OSAHS患者和17例单纯打鼾者,利用SF-36量表评估生活质量,白天嗜睡(excessivedaytimesleepiness,EDS)用ESS(epworthsleepinessscale)量表评分。对比研究SF-36各领域得分和患者基本信息、多导睡眠监测(polysomnography,PSG)各参数、EDS分值的关系,利用简单相关和多元逐步回归等统计学方法进行分析。结果简单直线相关分析结果显示:SF-36中有三个领域的分值和人体质量指数(bodymassindex,BMI)成负相关,有四个领域的分值和EDS高度负相关,有三个领域的分值及总分和最低血氧饱合度有一定的相关性,有两个领域的分值和睡眠呼吸最长暂停时间有一定的负相关性;多元逐步回归结果显示:睡眠呼吸暂停低通气指数(apneahypopneaindex,AHI)、低血氧症等对身体健康只产生比较小的影响,肥胖、EDS总分对SF-36内相关领域影响较大。结论重度OSAHS患者生活质量的某些领域相比单纯打鼾和轻度OSAHS患者受损严重;BMI、EDS和重度OSAHS患者的生活质量密切相关;OSAHS对患者的生活质量有负面影响。

OBJECTIVE To investigate the effects of obstructive sleep apnea hypopnea syndrome on the quality of life of the patients. METHODS The quality of life was assessed with the Medical Outcomes Study SF-36 Health Survey in 145 patients with OSAHS and 17 snorers without OSAHS. Excessive Daytime Sleepiness was assessed with Epworth Sleepiness Scale. Pearson linear correlation and stepwise multiple regression analysis were used to study the association between each domain score of SF-36 and patients information,PSG parameters,EDS scores. RESULTS Three domains of SF-36 correlated negatively with Body Mass Index. Four domains correlated negatively with EDS. Three domains and total score correlated significantly with the lowest oxygen saturation. Two domains correlated negatively with the longest time of apnea. AHI and the lowest oxygen saturation have a mild side effect on the quality of life. BMI and EDS score have significantly side effect on the quality of the life. CONCLUSION Comparing to the mild OSAHS patients and snorers without OSAHS,the severe OSAHS patients have worse quality of life. EDS score and BMI have a significantly side effect on the severe OSAHS patients. OSAHS has a side effect on the quality of life of the patients.