甲状旁腺癌的诊断和治疗

Diagnosis and surgical treatment of parathyroid carcinoma

目的探讨甲状旁腺癌(parathyroid carcinoma,PTC)的诊断和治疗方法。方法回顾性分析8例PTC的临床资料。结果本组PTC占原发性甲状旁腺功能亢进症(primary hyperparathyroidism,PHPT)的5．7％,男女各4例,男性发病年龄较轻。其病程明显短于其他PHPT患者。6例以急性高血钙症状就诊,7例可扪及颈部肿块。患者血钙(3．75±0．34)mmol/L,甲状旁腺激素水平为(1429．47±841．75)pg／ml。仅1例术中冰冻明确诊断。4例接受甲状旁腺癌根治手术,随访10-58个月血钙正常。另4例接受肿瘤摘除术,其中3例在术后12-18个月复发。结论PTC急性高钙症状较多见,术中冰冻诊断价值有限。首次手术时根治切除是影响预后最重要的因素。

Objective To evaluate the diagnosis and surgical treatment of parathyroid carcinoma （PTC）. Methods Clinical data of 8 PTC cases were analyzed retrospectively. Results PTC accounted for 5. 7% of patients with primary hyperparathyroidism （PHPT） in our hospital. There were 4 men and 4 women. Male patients had younger mean onset age compared with female patients. The disease history of PTC was shorter than PHPT of benign causes. Six patients were admitted for acute hypercalcemia. Seven patients complained of palpable neck mass. Calcium level was 3. 75 ± 0. 34 retool/L, and PTH level was 1429.47±841.75 pg/ml. Frozen section established diagnosis in only one case. Four patients underwent radical en bloc resection. Other 4 cases received routine simple parathyroidectomy, 3 patients developed recurrence in 12 ～ 18 months postoperatively. Conclusions Acute hypercalcemia is common in PTC. Frozen biopsy diagnosis is not satisfactory. An initial en bloc resection of tumor and adjacent structures contributes most to the prognosis.