期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

单核巨噬细胞中的髓样细胞触发性受体-1在脓毒血症中的作用 被引量：2

原文传递
导出
摘要 髓样细胞触发受体(TREM)是新近发现的免疫球蛋白超家族成员,目前至少有5个成员被发现。其中单核巨噬细胞中的TREM-1已证明在脓毒血症中起重要作用,它选择性的表达于血液中性粒细胞和单核细胞。TREM-1可被脂多糖(LPS)上调,促进炎症因子如白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)、巨噬细胞趋化蛋白-1(MCP-1)等的分泌,触发和放大单核细胞中的炎症反应。靠DAP12的帮助,TREM-1能激活下游信号活动,而TREM-1的溶解形式sTREM-1目前也被认为是代表感染后炎症反应的一个负反馈调节器。通过对TREM-1的作用及转导途径的研究,可对脓毒血症的防治和诊断带来积极影响。
作者 廖锐 沈客 龚建平
机构地区 重庆医科大学附属第二医院肝胆外科 重庆市第五人民医院
出处 《国际外科学杂志》 2006年第5期383-386,共4页 International Journal of Surgery
基金 国家自然科学基金资助项目(30471696 30500473)
关键词 单核巨噬细胞 髓样细胞触发受体-1 脓毒血症
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献1

二级参考文献46

  • 1[1]Kaisho T,Akira S.Pleiotropic function of Toll-like receptors.Microbes Infect 2004;6:1388-1394
  • 2[2]Medzhitov R,Janeway C Jr.Innate immunity.N Engl J Med 2000;343:338-344
  • 3[3]Janeway CA Jr,Medzhitov R.Innate immune recognition.Annu Rev Immunol 2002;20:197-216
  • 4[4]Ozinsky A,Underhill DM,Fontenot JD,Hajjar AM,Smith KD,Wilson CB,Schroeder L,Aderem A.The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.Proc Natl Acad Sci USA 2000;97:13766-13771
  • 5[5]Akira S,Hemmi H.Recognition of pathogen-associated molecular patterns by TLR family.Immunol Lett 2003;85:85-95
  • 6[6]Donnelly RP,Dickensheets H,Finbloom DS.The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.J InterferonCytokine Res 1999;19:563-573
  • 7[7]Kopp E,Medzhitov R.Recognition of microbial infection by Toll-like receptors.Curr Opin Immunol 2003;15:396-401
  • 8[8]Bone RC.Sir Isaac Newton,sepsis,SIRS,and CARS.Crit CareMed 1996;24:1125-1128
  • 9[9]Bone RC,Grodzin CJ,Balk RA.Sepsis:a new hypothesis for pathogenesis of the disease process.Chest 1997;112:235-243
  • 10[10]Davies MG,Hagen PO.Systemic inflammatory response syndrome.Br J Surg 1997;84:920-935

共引文献8

同被引文献24

  • 1Lambert GP,Gisolfi CV,Berg DJ,et al.Selected contribution:hyperthermia-induced intestinal permeability and the role of oxidative and nitrosstive stress[J].J Appl Physiol,2002,92 (4):1750-1761.
  • 2Dokladny K,Ye D,Kennedy JC,et al.Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression[J].Am J Pathol,2008,172(3):659-670.
  • 3Satoh M,Lindahl T.Role of poly (ADPribose) formation in DNA repair[J].Nature,1992,356(6367):356-358.
  • 4Thies RL,Autor AP.Reactive oxygen injury to cultured pulmonary artery endothelial cells:mediation by poly (ADP-ribose) polymerase activation causing NAD depletion and altered energy balance[J].Arch Biochem Biophys,1991,286(2):353-363.
  • 5Berger NA.Poly (ADP-ribose) in the cellular response to DNA damage[J].Rad Res,1985,101(1):4-15.
  • 6Szab C,Lim LH,Cuzzocrea S,et al.Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects[J].J Exp Med,1997,186(7):1041-1049.
  • 7Szab C,Vir g L,Cuzzocrea S,et al.Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase[J].Proc Natl Acad Sci USA,1998,95(7):3867-3872.
  • 8Mota RA,Hernández-Espinosa D,Galbis-Martinez L,et al.Poly (ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury[J].Crit Care Med,2008,36(2):526-534.
  • 9Hall DM,Buettner GR,Oberley LW,et al.Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia[J].Am J Physiol Heart Circ Physiol,2001,280(2):H509-H521.
  • 10Bouchama A,Parhar RS,el-Yazigi A,et al.Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke[J].J Appl Physiol,1991,70(6):2640-2644.

引证文献2

二级引证文献4

国际外科学杂志
2006年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部