蛋白酪氨酸磷酸酯酶-1B抑制剂的研究进展

Advances in the inhibitors of protein tyrosine phosphatase-1B

蛋白酪氨酸磷酸酯酶-1B(PTP-1B)是蛋白酪氨酸磷酸酯酶(PTP)家族中最具代表性的成鼠,因其参与多种生理过程尤其是与机体对胰岛素的敏感性紧密相关,目前已经成为糖尿病和肥胖症治疗的新靶点。现从PTP简介、PTP-1B的结构、生理功能以及6类抑制剂的结构性质等方面进行综述。

As one of the most members in the family of protein tyrosine phosphatases（PTPs）,protein tyrosine phosphatase-1B （PTP-1B） plays best-known roles in regulating physiological processes, especially in down regulation of insulin signaling. PTP-1B inhibitors may thus serve as novel medicinal agents for the treatment of type 2 diabetes mellitus and obesity. This article gives an overview of reports that have appeared in the primary scientific literatures on the development of PTP-1B inhibitors,including PTP-1B＇s structural characteristics and physiological functions as well as the structural properties of six kinds of the PTP inhibitors.