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静脉麻醉药对QT间期的影响 被引量:2

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摘要 QT间期是指QRS波开始到T波结束,代表心室的除极和复极两个过程。QT间期延长可引起突发性室性心律失常或室颤而导致猝死,在麻醉和手术期间危险性极大。本研究目的是观察临床常用静脉全麻药对QT间期的影响,以提高麻醉安全性。 资料和方法 选ASAⅠ级择期全麻手术病人45例,男性27例,女性18例,年龄14~45岁,体重35~70kg。五官科手术39例,胸部手术6例,随机分为硫喷妥钠组、异丙酚组和依托咪酯组。全部病例术前均无心血管及肝肾疾患,生化检查:钠、钾、氯、钙、磷、镁在正常范围,心电图检查QT间期和QTc正常。术前肌注安定10mg,入手术室后测血压、脉搏、用日本产5403型三笔式心电图机描记心电图做术前对照。
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 1996年第3期137-138,共2页 Journal of Clinical Anesthesiology
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同被引文献14

  • 1Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell, 2001,104 : 569-580.
  • 2Zhang L,Timothy KW,Vineent GM, et al. Spectrum of ST- T-wave patterns and repolarization parameters in congenital long-QT syndrome..ECG findings identify genotypes. Circulation, 2000,102 : 2849-2855.
  • 3Priori SCJ, Napolitano C, Schwartz PJ. Low penetrance in the long-QT syndrome: clinical impact. Circulation, 1999, 99:529-533.
  • 4Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation, 2001, 103:89-95.
  • 5Wilton NC, Hantler CB. Congential long QT syndrome; changes in QT interval during anaesthesia with thiopental, vecuronium,fentanyl and isofturane. Anesth Analg, 1987, 66: 357- 360.
  • 6王家和等.七氟醚对各器官系统的影响[J].中华麻醉学杂志,1995,15:341-341.
  • 7Lischke V, Behne M, Doelken P, et al. Droperidol causes a dose-dependent prolongation of the QT interval. Anesth Analg, 1994,79 : 983-986.
  • 8Lawrence KR, Nasraway SA. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: a review of the literature. Pharmacotherapy, 1997,17:531-537.
  • 9CUNEO BF. The beginnings of long QT syndrome[ J]. Curr Opin Cardiol,2015,30(1) :112.
  • 10MICHELS G, KOCHANEK M, PFISTER R. Life-threaten- ing cardiac arrhythmias due to drug-induced QT prolonga- tion:a retrospective study over 6 years from a medical in- tensive care unit [ J ]. Med Klin Intensivmed Notfmed, 2015. [ Epub ahead of print~.

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