碘缺乏病患者机体抗氧化能力的临床研究

Clinical study on cellular ability of antioxidation in iodine deficiency patients

对新疆阿克苏缺碘地区的４３名克汀病人，１５名地甲肿患者和１６名当地正常人的细胞抗氧化能力进行了临床观察，结果表明碘缺乏病患者的ＳＯＤ，ＧＰｘ活性明显下降，而ＬＰＯ含量显著增高；ＳＯＤ／ＬＰＯ，ＧＰｘ／ＬＰＯ均降低；其中克汀病人表现尤为突出。三型克汀病人之间（神经型，粘肿型和混合型）的抗氧化能力无显著差异。该研究表明，碘缺乏病患者机体抗氧化能力下降，自由基对机体的持续性损伤机制可能与碘缺乏病的发生和发展过程有关，故它可能是因缺碘而诱发的继发性病理因素。

he clinical study of cellular ability of antioxidation was conducted in 43 cretins,15 goitrous patients and 16 local normal persons of Xinjiang.The results showed that the activity of SOD,GPx was reduced and LPO content was increased markedly in IDD patients compared with those of the normal persons.The ratio of SOD/LPO and GPx/LPO showed also decreased obviously in these patients,especially in cretins.But there was no difference in antioxidation capacity among three types of cretinism patients.These results indicated that the antioxidation ability was reduced in IDD patient and the sustained tissue damage caused by free radicals may take part in pathogenesis of onset and progress of IDD,therefore it might be a secondary pathological factor induced by iodine deficiency.