碘缺乏病监测指标的探讨

Exploration for monitoring indicator of iodine deficiency disorders(IDD)

对５７例新生儿及其孕母配对研究ＴＳＨ、尿碘水平及相关分析。结果：新生儿ＴＳＨ＞５ｍＩＵ／Ｌ者占３２．７％，向高值方向偏移，表明该地区新生儿仍有碘缺乏。新生儿尿碘值与其自身ＴＳＨ水平呈高度负相关（ｒ＝－０．７１，Ｐ＜０．０１），孕母尿碘值与新生儿ＴＳＨ值呈负相关（ｒ＝－０．３４，Ｐ＜０．０５），新生儿尿碘值与其孕母尿碘值呈高度正相关（ｒ＝０．８２，Ｐ＜０．０１）。孕母尿碘值与新生儿尿碘值无显著差异。孕母尿碘值基本反映新生儿尿碘水平。因此，若采用孕母尿碘值作为ＩＤＤ监测指标，可直接反映胎儿和新生儿的碘营养水平，而胎儿和新生儿时期更需要足够碘供应，以保护脑发育，故若采用孕母尿碘值作为ＩＤＤ监测指标更有意义。

The TSH and urinary iodine levels,as well as the relations between these two indicators of the pregnant women and their neonates were studied.The results showed that the percentage of neonates with TSH levels greater than 5 mIU/L was 32.7%.It drifted toward higher level and indicated that the neonates in this area remained iodine deficiency.The urinary iodine levels of the neonates were inversely related to the TSH levels of themselves (r=-0.71, P <0.01).The urinary iodine levels of pregnant women were also inversely related to the TSH levels of the neonates(r=-0.34, P <0.05). The urinary iodine levels of the neonates were positively related to the urinary iodine levels of the pregnant women(r=0.8, P <0.01).There were no significantly differences between the urinary iodine levels of the pregnant women and neonates.The urinary iodine levels of pregnant women can nearly reflect the urinary iodine levels of neonates.Therefore,if the urinary iodine values of pregnant women is used for the index of monitoring IDD,it can reflect the iodine nutrition status of foetus and neonates directly.The foetus and neonates need even more iodine supply to protect their brain development.The urinary iodine values of pregnant women is much more significant in IDD surveillance.