Fas及Bcl-2在鼻息肉组织中的表达及意义

Significance of Fas and Bcl-2 expressions in nasal polyps

目的:探讨Fas和Bcl-2在鼻息肉组织中的表达及与鼻息肉发病的关系。方法:应用S-P免疫组化法检测36例鼻息肉组织及19例下鼻甲组织中Fas和Bcl-2的表达情况。结果:(1)Fas在鼻息肉上皮及腺上皮的表达弱于对照组(P<0.05);(2)Bcl-2在鼻息肉上皮及腺上皮的表达强于对照组(P<0.05);(3)鼻息肉上皮细胞中Fas、Bcl-2蛋白的表达无相关性(P>0.05)。结论:(1)Fas和Bcl-2在鼻息肉发生发展中起重要作用;(2)在NP上皮细胞中,Fas和Bcl-2无相关性,因此这两种凋亡基因在NP的形成过程中各起独立作用,协调抑制NP上皮细胞的凋亡。

Objective： To study the expressions of Fas and Bcl-2 in nasal polyps and explore the relationship between the two apoptosis-related proteins in formation of nasal polyps. Methods： Expressions of Fas and Bcl-2 were detected with S-P immunohistochemical method in 36 nasal polyps and 19 inferior turbinates. Results： （1） The expression of Fas in epithelial cells and epithelial cells of glands was significantly lower in nasal polyps than in inferior turbinates （ P 〈 0.05） ; （2） The expression of Bcl-2 in epithelial ceils and epithelial cells of glands was significantly higher in nasal polyps than in inferior turbinates （ P 〈 0.05 ） ; （3） The expressions of Fas and Bcl-2 had no correlation with each other in epithelial cells of nasal polyps（ P 〉 0.05）. Conclusion： （1） Fas and Bcl-2 may play important role in the occurrence and progression of nasal polyps; （2） No relationship is found between Fas and Bcl-2 in inhibiting the epithelial cells of glands of nasal polyps.