阻塞性睡眠呼吸暂停低通气综合征与代谢综合征的相关性

Relationship between obstructive sleep apnea hyponea syndrome and metabolic syndrome

目的:探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者代谢综合征(MS)的发生率及两者的相关性。方法:依据多导睡眠监测(PSG)结果,将52例OSAHS患者分为轻度、中度、重度3组,11例健康体检者作为正常对照。根据临床表现、血液生化指标、血压检查诊断代谢综合征,分析不同程度睡眠呼吸暂停患者代谢综合征的发生率。结果:体重指数(BMI)与呼吸暂停低通气指数(AHI)呈显著正相关,中、重度OSAHS组的高血糖、高血压、血脂紊乱、代谢综合征的发生率均明显高于正常组(P<0.05或0.01),轻度OSAHS组上述异常的发生率与正常对照组比较差异无统计学意义(P>0.05)。结论:睡眠呼吸暂停的程度与代谢综合征的发生呈正相关,MS患者是OSAHS的高危人群。

Objective： To discuss the morbidity of metabolic syndrome（MS） in patients with obstructive sleep apnea hyponea syndrome（OSAHS） and to investigate the correlation between severity of sleep apean and metabolic syndrome. Methods： Fifty-two patients with OSAHS were selected and divided into mild, moderate, and severe sleep apnea syndrome groups according to the results of polysomnography （PSG）. The diagnosis of metabolic syndrome was made according to symptoms, physical signs, blood biochemical parameters and blood pressure. The incidence of metabolic syndrome in patients with obstructive sleep apnea hyponea syndrome of different levels was analyzed. Results： Body mass index（BMI） was significantly correlated to appnea-hypopnea index（AHI）（ r = 0.389）. The morbidity of metabolic syndrome in moderate and severe sleep apnea syndrome groups was significantly higher than that in normals and mild sleep apnea syndrome groups. Condusions： There is a significant positive correlation between the severity of obstructive sleep apnea hyponea syndrome and metabolic syndrome. The results suggesed that obstructive sleep apnea hytxama syn- drome plays an important role in the pathogenesis of some metabolic syndrome.