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奥利司他合成路线图解 被引量:4

Graphical Synthetic Routes of Orlistat
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出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第10期716-720,共5页 Chinese Journal of Pharmaceuticals
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参考文献16

  • 1Hanessian S,Tehim A,Chen P.Total synthesis of (-)-tetrahydrolipstatin[J].J Org Chem,1993,58 (27):7768-7781.
  • 2Pons J-M,Kocienski P.A synthesis of (-) -tetrahydrolipstatin[J].Tetrahedron Lett,1989,30(14):1833-1836.
  • 3Barbier P,Schneider F,Widmer U.Stereoselective syntheses of tetrahydrolipstatin and of an analogue,potent pancreaticlipase inhibitors containing a β-lactone moiety[J].Helv Chim Acta,1987,70:1412-1418.
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同被引文献22

  • 1苏金环,郭皓,曾聪明,文军.生物催化不对称还原制备(R)-2-羟基-4-苯基丁酸[J].精细化工中间体,2012,42(3):35-38. 被引量:1
  • 2杨小波,陈再新,张奕华.奥利司他的全合成研究进展[J].有机化学,2005,25(8):902-912. 被引量:4
  • 3肖松,朱小兰,陈波,姚守拙,王竹天,杨大进,韩宏伟.减肥保健食品中奥利司他的HPLC-UV-ESI-MS的测定[J].卫生研究,2006,35(3):355-356. 被引量:8
  • 4黄世杰.由于致癌危险美国消协要求奥利司他撤出市场[J].国外医学(药学分册),2006,33(5):328-328. 被引量:6
  • 5Hanessian S, Tehim A, Chen P. Total synthesis of ( - ) - tetrahydrolipstatin[J]. J Org Chem, 1993,58 (27) :7768 - 7781.
  • 6Barbier P, Schneider F. Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and |ipstatin [ J ]. Helv Chim Acta, 1987,70 ( 1 ) : 196 - 202.
  • 7Anne B, Steven RP. Orlistat: its current status as an anti - obesity drug [ J ]. Euro J Pharmaco ,2002,440 ( 1 ) : 109 - 117.
  • 8Zhi J, Mulligan TE, Hauptman JB. Long - term systemic exposure of orlistat, a lipase inhibitor, and its metabolites in obese patients[ J]. Clin Pharmacol, 1999,39 ( 1 ) :41 - 46.
  • 9Sjostrom L, Rissanen A, Adersen T, et al. Randomised placebocontrolled trial of orlistat for weight loss and prevention of weight regain in obese patients [ J ]. Lancet, 1998,352 ( 9123 ) : 167 -173.
  • 10Davidson MH, Hauptman J, DiGirolamo M, et al. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat. A randomized controlled trial[J]. JAMA, 1999,281 ( 3 ) : 235 - 242.

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