摘要
通过测定特异性抗体、淋巴细胞转化和巨噬细胞（ＭΦ）吞噬率，观察卡介菌多糖核酸（ＢＣＧ－ＰＳＮ）和死卡介菌（死卡）对抗环磷酰胺（ＣＴＸ）免疫抑制的作用。结果显示：ＢＣＧ－ＰＳＮ和死卡能增加小鼠有核脾细胞和腹腔细胞数、促进Ｔ淋巴细胞转化、促进血凝抑制抗体产生和增强ＭΦ的吞噬功能。ＣＴＸ对上述免疫细胞均有不同程度的抑制作用，尤对Ｂ细胞产生抗体的抑制作用最强。ＢＣＧ－ＰＳＮ和死卡对ＣＴＸ的免疫抑制有不同程度的保护作用，尤对ＭΦ吞噬功能保护力最强。结果提示，ＢＣＧ－ＰＳＮ可望用于临床使用ＣＴＸ的病人以增强免疫力。
he effects of BCG-polysaccharide nucleic acid fraction(BCG-PSN)and heat-killed BCGon immunosuppression induced by cyclophosphamide were studied.BCG-PSN and heat-killedBCG were found to be capable of increasing the number of splenic cells and macrophages and ofenhancing the function of splenic T cell,B cell and macrophage in mice. Cyclophosphamide wascapable of inhibiting the function of T cell,B cell and macrophage especially on the B cell.BCG-PSN and heat-killed BCG were capable of resisting immunospuppression induced by cyclophos-phamide to a certain extent.
出处
《湖南医科大学学报》
CSCD
1996年第4期281-284,共4页
Bulletin of Hunan Medical University
基金
中国科学院科学基金
关键词
卡介菌多糖核酸
死卡介菌
环磷酰胺
免疫抑制
BCG-polysaccharide nucleic acid
Heat-killed BCG
cyclophosphamide
splenic T cell
Macrophage
