丙型肝炎病毒感染者自身抗体的检测及其临床意义

DETECTION OF AUTO-ANITBODIES IN HCV CARRIERS AND THEIR CLINICAL SKGNIFICANCE

检测３５例抗－ＨＣＶ阳性者的自身抗体情况，并与３０例ＨＢｓＡｇ阳性者及３２例正常人作对照。结果发现，ＨＣＶ阳性者ＥＮＡ阳性率为４２．９％，自身抗体总检出率为６２．９％，均明显高于正常对照组及ＨＢｓＡｇ阳性者（Ｐ＜０．０５）。提示抗－ＨＣＶ及ＨＢｓＡｇ阳性者可检出某种自身抗体，表明其免疫系统已受到不同程度的损害，应及时采取防治措施。讨论了丙型肝炎与自身免疫性肝炎的关系。

xtractable nuclear antibody(ENA),anti-nuclear antibody(ANA)and rheumatoid factor(RF)were determined in 35 cases of anti-hepatitis C virus(anti-HCV)carriers,30 cases of HB-sAg carriers and 32 cases of control.The total positive rate of auto-antibodies(62.9%)and thepositive rate of ENA(42.9%)in group of anti-HCV carriers were higher than those in group ofHBsAg carriers(33.3%and 16.7%)and in control group(6.2%and 3.1%)(P<0.05,P<0.01).The results indicate,when some auto-antibodies are determined in the anti-HCV andHBsAg carriers,their immune system is being injured.The relationship between hepatitis C andautoimmune hepatitis are discussed.