何杰金氏病增殖细胞核抗原的表达

THE EXPRESSION OF PROLIFFERATIVE CELL NUCLEAR ANTIGEN IN HODGKIN'S DISEASE

不同时期的典型何杰金氏病１８例，用抗ＰＣ＿（１０）、Ｌ＿（２６）、ＵＣＨＬ－１抗体作ＳＰ免疫组化染色。结果显示：无一例阴性病例。ＰＣ＿（１０）阳性的ＨＲＳ细胞百分率与传统分类比较有相关性。Ｌ＿（２６）和ＵＣＨＬ＿１阳性细胞的百分率分别为１１．３％～２１．５％和３８．２％～４９．５％。表明不存在单一的Ｂ或Ｔ细胞免疫表达。提示ＨＲＳ细胞与背景中淋巴细胞之间其细胞来源有内在联系。

ighteen cases of Hodgkin's Disease(HD)were analyzed immunohistochemically.Amongthem,there were 5 cases of LP,4 cases of MC,6 cases of NSand 3 cases of LD,Apal1el ofanti-bodies composed of PC_10,L_26,UCHL-1,was used for Hodgkin's cells and Reed-Sternberg cells(HRS cell)and lymphocytes of all 18 cases were positive.It suggests that PCi0 may be a markerfor reflecting the biological behavior of HD.The positive rates of L26 and UCHL-1 in the back-ground lymphocytes were 11.3%～21.5%and 38.2%～49.5%respectively.It indicates thatlymphocytes in 18 cases of HD are composed of T and B cells,these cells seem to be around theHRS cell.The data perhaps will be valuable in understanding the relationship between HRS cellsand lymphocytes.