The application of in vitro maturation of oocytes in the infertile patients with polycystic ovarian syndrome

Objective:To evaluate the effects of in vitro maturation(IVM)of oocytes in the infertile pa-tients with polyeystic ovarian syndrome(PCOS).Methods:The infertile patients with PCOS who underwent IVM or IVF/ICSI from January2004 to August 2005 were studied retrospectively.68 unstimulated cycles(48 cases)underwentIVM as IVM group,42 cycles(39 cases)underwent IVF/ICSI as control group.Main outcomesincluding the number of oocytes retrival,the rates of fertilization,embryo cleavage,implanta-tion,pregnancy,miscarriage,ovarian hyperstimulation syndrome(OHSS)and multiple pregnan-cy were assessed.Results:No FSH was administered in IVM group and the mean number of FSH used was(25±6.2)ampoules in control group.When compared with control group,women in IVM grouphad significant increase in fertilization rate(70.7% versus 63.9%)and decrease in cleavage rate(87.9% versus 99.4%)and ovarian hyperstimulation syndrome(0 versus 7.1%).No significantdifferences between IVM group and control group were found in the number of oocytes obtained,implantation rate,clinical pregnancy rate,miscarriage rate and multiple pregnancy rate.Conclusion:Our results suggested that for infertile PCOS women who required assisted con-ception treatment,IVM is a more economical method with less OHSS complication than that ofconventional IVF treatment.

Objective. To evaluate the effects of in vitro maturation （IVM） of oocytes in the infertile patients with polycystic ovarian syndrome（PCOS）. Methods. The infertile patients with PCOS who underwent IVM or IVF/ICSI from January 2004 to August 2005 were studied retrospectively. 68 unstimulated cycles （48 cases） underwent IVM as IVM group, 42 cycles （39 cases） underwent IVF/ICSI as control group. Main outcomes including the number of oocytes retrival, the rates of fertilization, embryo cleavage, implanta- tion, pregnancy, miscarriage, ovarian hyperstimulation syndrome （OHSS） and multiple pregnancy were assessed. Results： No FSH was administered in IVM group and the mean number of FSH used was （25±6.2） ampoules in control group. When compared with control group, women in IVM group had significant increase in fertilization rate （70.7% versus 63.9%） and decrease in cleavage rate （87.9 % versus 99.4%） and ovarian hyperstimulation syndrome （0 versus 7.1%）. No significant differences between IVM group and control group were found in the number of oocytes obtained, implantation rate, clinical pregnancy rate, miscarriage rate and multiple pregnancy rate. Conclusion：Our results suggested that for infertile PCOS women who required assisted conception treatment, IVM is a more economical method with less OHSS complication than that of conventional IVF treatment.