丙戊酸钠治疗155例精神疾病疗效分析

A Preliminary Clinical Study of Sodium Valproate in the Treatment of Mental Illness

用丙戊酸钠治疗１５５例精神病人，疗程８周，临床总有效率６０％。对情感高涨、易激惹、失眠疗效较好；对幻听、妄想有一定的疗效；对思维联想障碍、情感淡漠、生活懒散疗效欠佳。使用中未见严重不良反应。

The punpose of this study is to assess the efffectiveness of sodium valproate in the treatment of mental illness. One hundrad and fifty five psychiatric patients were treated openly by sodium valproate for 8 weeks, with 800-3000 mg/day. All of patients were rated blindly on CGI, TESS by two trained poychiatrists before the treatment, and in the first, second, fourth, sixth and eighth weeks after the tratment. The total improvement rate is 60%. Sodium valproate was found to be more effective in the treatment of elation irritability, insomnia and auditory hallucination and delusion, but to be less effective in the treatment of thought disturbance, apathy, social withdrawal. No serious further comprehensive study is required to verify the effectiveness of sodium valproate in the treatment of mental illness adverse effects in observed.