甲型和乙型病毒性肝炎患者血清可溶性白细胞介素－2受体水平变化

The Changes of Soluble Interleukin-2 Receptors Levels in the Serum of Hepatitis A and B Patients

检测了５６例甲型和乙型病素性肝炎患者血清可溶性白细胞介素－２受体（ｓＩ１－２Ｒ）水平。结果与对照组相比除乙肝病毒携带者外，其余患者血清ｓＩ１－２Ｒ水平均增高，ｓＩ１－２Ｒ水平与谷丙转氨酶、黄疸指数呈正相关。乙肝患者病毒复制活跃者ｓＩ１－２Ｒ水平升高亦较明显。本文表明，血清ｓＩ１－２Ｒ水平可作为临床病情监测和预后判断的一项指标。

The levels of soluble interleukin-2 receptors were detected in 356 cases of hepatitis A and B patients by using ELISA method. The result showed that sIL-2R levels in the serum of these patients were all at 36 8.9～1450.1U/ml,which were marked elevated than that of the control group(24.1U/ml)(P<0.05, P<0.01).The sIL-2R levels showed positive corelation with liver function deterioration and the degree of deplicating activity of hepatitis B virus. The levels in chronic type and severe type of hepatitis A and B were relatively higher while that in chronic persistent hepatitis and posthepatitic cirrliosis of liver were relatively lower.There were no marked difference in hepatitis B virus carriers and control group.Therefore the changes in serum sIL-2R level may reflect the pathological changes of the liver and the sererity of inflammation and it may be served as an indicator to monitor the diseased condition and prognostic judgment.