羧乙基锗倍半氧化物对大鼠脑缺血再灌注损伤的保护作用

The protective effects of cerebral carboxyethylgermanium sesquioxide on ischemia-reperfusion injury in rat

采用结扎双侧颈总动脉后再通的方法复制大鼠脑缺血再灌注损伤模型，通过测定再灌注后大鼠海马组织中脂质过氧化产物丙二醛（ＭＤＡ），超氧化物歧化酶（ＳＯＤ）与谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）及ＡＴＰａｓｅ的活性，观察了有机锗─羧乙基锗倍半氧化物（ＣＧＳ）对大鼠脑缺血再灌注后大鼠海马组织中ＭＤＡ水平，明显保护ＳＯＤ、ＧＳＨ─Ｐｘ、Ｎａ＋Ｋ＋─ＡＴＰａｓｅ及Ｃａ２＋─ＡＴ─Ｐａｓｅ活性。表明ＣＧＳ对大鼠脑缺血再灌注损伤具有保护作用。

In order to observe the influence of carboxyethylgermanium sesquioxide(CGS) on cerebral ischemia-reperfusion injury in rat,the animal model was established by ligaturing both sides of common carotid artery followed by ing. Levels of malondialehyde(MI)A) and activity of superoxide dismutase(SOD), glutathione peroxidase(GSHPx) and ATPase were determined in the hippocampus of brain that underwent ischemia following reperfusion. The data showed that CGS significantly decreased the level of MDA and had obviously a protective effect on the activity of SOD,GSH-Px, Na+-K+ATPase and Ca24-ATPase. The results suggested that CGS has a protective effect on cerebral ischemia reperfusion injury in rats.