缺血预适应与急性心肌梗死临床观察

Clinical study of ischemic preconditioning and acute myocardial infarction

目的研究缺血预适应对急性心肌梗死(AMI)的影响。方法选择胸痛发病6 h内并确诊为ST段抬高的AMI患者60例作为观察对象。根据发病前48 h内有无心绞痛史,将患者分为2组,每组30例。分别进行溶栓后,测定CK、CK-MB、EF以及住院期间发生左心衰和恶性室性心律失常的发生率,并进行比较。结果梗死前48 h内有心绞痛病史的患者有较低的CK、CK-MB峰值活性,住院期间泵衰竭及恶性心律失常的发生率低,且EF值较高。

Objective To study the effects of ischemic preconditioning on acute myocardial infarction（AMI）. Methods Sixty patients of cheat pain that were diagnosed ＂Q-Wave （ST-elevation） AMI＂ in six hours were chose, The cases were divided into two groups according to whether or not having previous angina pectoris in forty-eight hours before AMI, then each group had thirty cases. After the thrombolytic therapy, the quantity of creatine kinase, MB creatine kinase, ejection fraction（EF） of left ventricular, and the incidence of left heart failure and ventricular arrhythmia were measured, then the difference of the two groups was observed, Results The peak value of CK, CK-MB and the incidence of left heart failure and ventricular arrhythmia were lower in the group that having previous angina pectoris in forty-eight hours, and the EF value was higher.