持续静脉输注咪唑安定治疗惊厥性癫持续状态疗效观察

Therapeutic effects of midazolam on continuous status epileptics

目的观察咪唑安定持续静脉推注治疗惊厥性癫持续状态的临床疗效及副作用。方法选择住院的45例患儿为观察对象,随机分为2组,对照组21例,给予传统的一线抗癫药物;治疗组24例,给予咪唑安定持续静脉滴注。对比两组疗效,同时观察治疗组的用量及副反应。结果治疗组疗效明显优于对照组(P<0.05),咪唑安定的安全剂量小于8μg/(kg.min),小于此用量时无明显副作用,用量≥10μg/(kg.min)时,3例出现呼吸抑制的副作用。结论咪唑安定持续静脉推注治疗惊厥性癫持续状态疗效优于传统的一线抗癫药物,大剂量应用时,需注意呼吸抑制的副作用。

Objective To observe the therapeutic effects of midazolam on continuous status epileptics （SE） by continuously given as a drip infusion, and to investigate the safe dosage and adverse reaction of it. Methods Forty-five children with SE were divided into two groups： in control group（24 cases）, midazolam was continuously given as a drip infusion; in treatment group（21 cases）, routine first-line anti-epileptic drugs （AEDs） was used, then comparing the therapeutic effects, and the safe dosages and side effects of midazolam were checked. Results There was significant difference in therapeutic effect of two groups （P 〈 0.05）. The safe dosage of midazolam was less than 8 μg/（kg·min）, and no serious side effect was observed. Respiratory depression was found in 3 cases when its dosage was more than 10μg/（kg·min）. Conclusion The effect of midazolam on SE by continuously iv is better than the routine first-line AEDs. Respiratory depression must be cared when midazolam＇s dosage was more than 10μg/（kg·min）.