急性脑梗塞与血清白细胞介素-6关系的初步探讨

A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN SERUM INTERLEUKIN-6 AND ACUTE CEREBRAL INFARCTION

用双抗体夹心ＥＬＩＳＡ法对４６例急性脑梗塞患者血清ＩＬ－６含量作了检测，结果显示：脑梗塞急性期和恢复期两组均明显高于健康人对照组（Ｐ＜０．００５，Ｐ＜０．０１）；恢复期组略低于急性期组，但无统计学意义（Ｐ＞０．０５）。急性期血清ＩＬ－６含量与脑梗塞估测体积呈正相关关系（ｒ＝０．６４，Ｐ＜０．０５），而与脑梗塞发生部位无关。脑梗塞体积越大，血清ＩＬ－６值越大，提示血清ＩＬ－６含量的测定可能作为早期判断急性脑梗塞脑损害程度的指标。

Serum IL-6 levels in 46 patients with acute cerebral infarction were detected by sandwich ELISA. The results showed that the IL-6 levels of acute stage and recovery stage were significantlyhigher than that of the control group(P<0. 005, <0. 01),and that of the recovery stage was a bit lowerthan that of the acute stage, but there was no statistical significance (P>0. 05). The serum IL-6 levels ofthe acute stage correlated positively with the infarction area size(r=0. 64),while there was no relationship between the position of cerebral infarction and the IL-6 level. It is concluded that the serum IL-6levels are increased in acute and recovery stage of acute cerebral infarction. The increased IL-6 level correlates not only with the transient acute phase response,but also with the inflammatory response to thefocal ischemic damage of the brain and the post-injury repair. The wider the infarction area and the higher the serum IL-6 level may acts as an index of judging the injury degree of acute cerebral infarction.