摘要
用双抗体夹心ELISA法对46例急性脑梗塞患者血清IL-6含量作了检测,结果显示:脑梗塞急性期和恢复期两组均明显高于健康人对照组(P<0.005,P<0.01);恢复期组略低于急性期组,但无统计学意义(P>0.05)。急性期血清IL-6含量与脑梗塞估测体积呈正相关关系(r=0.64,P<0.05),而与脑梗塞发生部位无关。脑梗塞体积越大,血清IL-6值越大,提示血清IL-6含量的测定可能作为早期判断急性脑梗塞脑损害程度的指标。
Serum IL-6 levels in 46 patients with acute cerebral infarction were detected by sandwich ELISA. The results showed that the IL-6 levels of acute stage and recovery stage were significantlyhigher than that of the control group(P<0. 005, <0. 01),and that of the recovery stage was a bit lowerthan that of the acute stage, but there was no statistical significance (P>0. 05). The serum IL-6 levels ofthe acute stage correlated positively with the infarction area size(r=0. 64),while there was no relationship between the position of cerebral infarction and the IL-6 level. It is concluded that the serum IL-6levels are increased in acute and recovery stage of acute cerebral infarction. The increased IL-6 level correlates not only with the transient acute phase response,but also with the inflammatory response to thefocal ischemic damage of the brain and the post-injury repair. The wider the infarction area and the higher the serum IL-6 level may acts as an index of judging the injury degree of acute cerebral infarction.
出处
《广东医学院学报》
1996年第3期216-218,共3页
Journal of Guangdong Medical College
关键词
脑梗塞
血清
白细胞介素6
免疫反应
cerebral infarction
serum
interleukin 6 (IL-6)
immune response