期刊文献+

病毒性肝炎患者血清肿瘤坏死因子α检测的临床意义

THE DETECTION OF SERUM TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH VIRAL HEPATITIS AND ITS CLINICAL SIGNIFICANCE
下载PDF
导出
摘要 用放射免疫分析法(RIA)测定45例正常人及206例病毒性肝炎病人血清肿瘤坏死因子α(TNFα)的含量,其中急性黄疸型肝炎(AIH)67例,慢性活动型肝炎(CAH)38例,慢性迁延型肝炎(CPH)36例,肝硬化(LC)40例,重症肝炎(SH)25例。结果显示,病毒性肝炎病人TNFα水平较正常人明显增高(22.42±18.37fmol/ml)(P<0.001),且与患者病情轻重密切相关。SH组TNFα较AIH组明显升高(P<0.01);CAH组TNFα较CPH组明显升高(P<0.01)。二种或二种以上肝炎病毒感染时较单一病毒感染时TNFα增高(P<0.05)。本文还观察了108例病情好转的病人,TNFα含量也下降(P<0.01),而5例病情恶化的病人TNFα含量明显增高,最高1例达78.80fmol/L在病情中TNFα持续不下降或逐渐上升时,提示病情可能向重型转变,这一结果说明TNFα水平的变化,可以反映肝细胞病变程度,与病毒性肝炎的活动性相关。 Serum tumor necrosis factor alpha(s TNF α)was measured by radioimmunoassay in 206 patients with different types viral hepatitis and 45 normal persons as controls,The results showed that the s TNFα levels were significantly increased in patients with viral hepatitis as compared with controls(22.42±18.37fmol/ml vs9.45±5.00fmol/ml ,mean±sd P<0.001),and closely related to the severity of disease. The levels of sTNFα were higher in two or more than two hepatitis virus coinfection or superinfection than thosein sigle virus infection inpatients(P<0.05).The sTNFαlevels in 108 patients decreased gradually as their symptoms and signs were improved, while the value of sTNFα in 5 severe cases quikly increased as the conditions were worse(highest to 78.80fmol/ml in one case).The results suggest that the increased level of sTNFα in viral hepatitis may be associated with the degree of injury of hepatocytes and hepatitis activity.
出处 《广东医学院学报》 1996年第2期116-118,共3页 Journal of Guangdong Medical College
关键词 病毒性肝炎 肿瘤坏死因子Α viral hepatitis TNFα
  • 相关文献

参考文献1

二级参考文献3

  • 1边中启,中华传染病杂志,1992年,10期,88页
  • 2李彪如,上海第二医科大学学报,1990年,10期,189页
  • 3张定凤,中华医学杂志,1990年,70卷,438页

共引文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部