检测胸水与血清的唾液酸、癌胚抗原及乳酸脱氢酶对鉴别良、恶性胸水的价值

DIFFERENTIATION BETWEEN BENIGNANT AND MALIGNANT HYDROTHORAXES BY DETERMINING SA,CEA AND LDH IN SERUM PLUS PLEURAL FLUID

检测良、恶性胸水患者各２０例的血清与胸液的唾液酸（ＳＡ）、癌胚抗原（ＣＥＡ）、乳酸脱氢酶（ＬＤＨ）和４０例健康人的血清ＳＡ的结果表明：（１）良、恶性胸水患者的血清ＳＡ均高于正常人组（Ｐ＜０．０１），但良、恶性两组间比较差异不显著（Ｐ＞０．０５）；（２）良、恶性胸水患者的胸水与血清ＳＡ、ＣＥＡ、ＬＤＨ及ＳＡ＋ＣＥＡ联合，ＳＡ＋ＣＥＡ＋ＬＤＨ联合检测，鉴别良、恶性胸水以ＣＥＡ（胸液／血清比值≥１．５）最优，特异性高达９５％，敏感性为５５％。

In 20 patients with malignant and benignant pleural fluid and 40 heathy subjects as control gnoup, the levels of sialic acid(SA),carcinoembryonic antigen(CEA)and lactate dehydrogenase(LDH)were detected by single reagent colorimetry, ELISA and enzymekinesic method,respectively.The results showed that:(1)the serum level of SA is higher in patients with hydrothoraxes whether benign or malignant than that in the control group; (2)the ratio of pleural fluid to serum CEA(≥1.5),of which the specificity and sensitivity is 95%and 55% respectively, is superior to corresponding ratio of SA or LDH for differenriation between benign and malignant hydrothoraxes.